Technical University of Denmark
COMPOUND LIBRARY:
The compound library of DK-OPENSCREEN is hosted and curated by DTU Chemistry, where assay-ready plates are prepared and distributed to DK-OPENSCREEN screening nodes as well as external partners. We have state-of-the-art equipment ensuring highly efficient screening compound synthesis, hit triaging, quality control and assurance as well as compound management. We also offer the expertise to do follow-up chemistry in order to turn screening hits into useful tool compounds or early drug leads.
HIGH-THROUGHPUT SCREENING:
DTU Screening Core provides state-of-the-art facilities for medium and high throughput screeningin a fully automated Screening Core platform designed to perform biochemical and cell-based screenings. The platform offers great flexibility in terms of possible read-outs, such as fluorescence, absorbance, luminescence and imaging function among others. More info here.
University of Copenhagen
PATHOGENIC BACTERIA:
The Costerton Biofilm Center specializes in antimicrobial screening directed against chronic infections. The node utilizes high-throughput screening to study and identify small molecules that are either bacteriostatic or productively interfere with biofilm formation.
The lead compounds identified in screening campaigns will block bacterial communication and developmental processes and circumvent the risk of drug-resistance, revolutionizing treatment of antibiotic-resistant infections, long-term prevention and treatment of chronic infections, and anti-bacterial cancer prevention and therapy. The node will develop new targets for biological screenings and is capable of performing screening campaigns directly against pathogenic bacteria in specialized GMO Class 2 laboratories.
PHENOTYPIC SCREENING:
The core facility for High Throughput Cell Based Screens at BRIC offers high-throughput screening services utilizing phenotypic image-based analysis as primary readout. It is equipped with state-of-the-art robotic liquid handling stations, automated high content image analysis systems and has access to a HT flow based analysis platform. This DK-OPENSCREEN node provides expertise in cell-based assay development, high content image analysis, HT cell-based screening and statistical data analysis and visualization for chemical library screening. For more information please go to our website.
Aalborg University
BACTERIAL COMMUNITIES:
The Center for Microbial Communities specializes in new fundamental understanding of structure and function of microbial communities. The facility will contribute unprecedented high-throughput annotation of bacterial strains and communities and add knowledge of microbial ecology. The site has platforms for high-throughput DNA sequencing and expertise in screening microbial communities for the identity and function of the bacterial members. The center has extensive experience with samples from many environments, such as human infections, technical systems (bioenergy, water and wastewater treatment, nutrient recovery), and natural systems such as soil, lakes and sea.
Aarhus University
STRUCTURAL BIOLOGY:
The structural biology group at AU is a preferred partner for protein structure studies, structure-guided fragment-to-lead development and helps inform on hit-to-lead campaigns.